In the azoxymethane (AOM)/DSS mouse model of CRC, genetic inactivation of miR-21 reduced the tumor burden and decreased the expression of pro-inflammatory cytokines, and the loss of miR-21 in tumors also increased PDCD4 expression and apoptosis, but reduced the expression of activated STAT3 and BCL2 [81]. The gene discussed is STAT3; the disease is neoplasm.