The miR-17 family has eight miRNAs, including miR-17, miR-18a/b, miR-20a/b, miR-93, and miR-106a/b, and three of them (i.e., miR-17, miR-18a, and miR-20a) are transcribed from the miR-17-92 locus.MiR-17 targets and inhibits PTEN [62] and RHOE (RND3) [63], a tumor suppressor that is downregulated in CRC and exhibits inhibition of cancer cell invasion [64]. The gene discussed is RND3; the disease is cancer.