ZEB1 and cancer: Interestingly, the expression of miR-141 and miR-200c could be suppressed by Zeb1; for instance, knockdown of Zeb1 leads to increases of miR-141, miR-200c, and E-cadherin expression, increases cell-cell adhesion, induces epithelial phenotype, and reduces cell migration and invasion [112].In contrast, overexpressing Zeb1 can facilitate EMT progression and promote cancer cell invasion via triggering a miRNA-mediated feed-forward loop.