Several measures can be adopted to limit the occurrence of clinically relevant OHSS, including but not limited to lower the starting dose of gonadotropins, step down protocols, antagonist based stimulation protocols, coasting, GnRH agonist (GnRHa) triggers, and cryopreservation of embryos with subsequent freeze-thaw transfer [2,3,7–10]. This evidence concerns the gene GNRH1 and ovarian hyperstimulation syndrome.