It is interesting to note that HLA-DRB is up-regulated in both IIM-GC and CIM-GC, that HLA-DRB4 overexpression was confirmed by RT-qPCR and that antigen presentation also is a common pathway in both IM-subtypes progressing to GC, altogether being in agreement with the immune response as an important process in the progression of precursor lesions to GC [37]. The gene discussed is HLA-DRB1; the disease is gastric cancer.