GRN and frontotemporal dementia: Moreover, given prior work linking the TMEM106B locus and the granulin precursor (GRN) gene, a Mendelian risk gene for frontotemporal lobar degeneration (FTLD) that is thought to be downstream of TMEM106B [37,47], we performed a secondary analysis of the GRN locus: the omnibus DNA methylation (p = 0.025) and mRNA level (estimated effect = −0.024, 95% CI −0.038 to −0.009, p = 0.0018) analyses of GRN revealed a modest association with residual cognition.