We therefore picked the minor alleles of the lead SNPs from each of the loci (Table 1): rs3846455G, within the first intron of UNC5C, and rs76662990G, close to ENC1. Both SNPs were then evaluated in greater detail in relation to predicted chromatin state, baseline cognitive scores, an individual’s pathology-adjusted slope of cognitive decline, and pathological burden. Here, ENC1 is linked to Mental deterioration.