Although the TMEM106B region showed no association with residual cognition in step 2, rs11509153A remains of interest because it is in strong LD (r2 = 0.66) with rs1990622G, an allele previously reported to be associated with a lower risk of TDP-43 proteinopathy [37,55]. The gene discussed is TMEM106B; the disease is proteostasis deficiencies.