Hotspots in cancer co-localized with genes that are enriched for extracellular glycoproteins, G-protein coupled receptors especially olfactory receptors, cell-cell adhesion, molecular species intrinsic to the plasma membrane, Ig- and EGF-like domains, ligand gated ion channels, membrane attack complex component/perforin, complement 9, cadherin, Sushi domains, potassium channels, Kazal proteinase inhibitors, fibronectin III, glycosylation, glycoproteins, the machinery to hydrolize and excrete proteins, and finally MHCI and MHCII. The gene discussed is CDH17; the disease is cancer.