TNFα evoked release of tumor-promoting chemokines such as CCL2 (MCP-1), CCL5 (RANTES) and CXCL8 (IL-8) [26] trigger infiltration of CCR2/CCR5 receptor bearing leukocyte sub-populations (LSPs) including TAMs [29], MDSCs [30], TANs[31,32], Tregs [33], MAMs and CAFs [34]. This evidence concerns the gene CCL2 and neoplasm.