Likewise, numerous studies show many of these signaling pathways are blocked by apigenin in tumor models [17] in particular NF-kB signaling [51,52] which controls the downstream release of TGF-b [53] and activity of MMP-9 [54], themselves involved with TAM/TANs [55–57] and Treg recruitment [44,45]. Here, MMP9 is linked to neoplasm.