TET2 and myeloid neoplasm: Although we have shown that the catalytic activity of TET2 is essential for its myeloid tumour-suppressive function in HSCs/HPCs19, our recent RNA-seq and 5mC/5hmC analyses on premalignant Tet2−/− and WT LK cells showed that distinct cytosine modifications (particularly 5hmC) often mark specific genes in Tet2−/− LK cells without altering their expression17.