WES analyses identified few mutations in premalignant LK cells from WT, Tet2+/− and Tet2−/− mice, because genetic changes would only be detectable in a dominant LK cell clone (Supplementary Data 4), so variants identified in Tet2−/− tumours are somatic mutations accumulating in Tet2−/− cells over time, rather than germline. This evidence concerns the gene TET2 and neoplasm.