These significant clusters included acute inflammatory response (P = 740.0E-9), response to peptide hormone (P = 3.4E-15), phagocytosis (P = 1.8E-6), regulation of endopeptidase activity (P = 14.0E-12), leukocyte proliferation (P = 25.0E-9), ERK1/2 cascades (P = 150.0E-12), granulocyte chemotaxis (P = 22.0E-9), positive regulation of a response to an external stimulus (P = 74.0E-24), TNF signaling pathway (P = 4.2E-6), proteoglycans in cancer (P = 530.0E-9) and cytokine activity (P = 140.0E-15) (Fig. 3b). Here, TNF is linked to cancer.