SRPX2 and Rolandic epilepsy: Specifically, we identified a private start-loss variant in ERC1, a gene previously implicated in childhood apraxia of speech45; a novel de novo substitution disrupting GRIN2A, a gene mutated in epilepsy-aphasia spectrum disorders36, 62, 63; and a hemizygous disruption of SRPX2 that has previously been identified in people with Rolandic epilepsy with speech apraxia34.