Figure 8 shows a network view of the impact of the IRF5−/− mutation during Chlamydia infection with large circles demonstrating genes that were potentially key hubs, for example, fibronectin (FN), epidermal growth factor receptor, transcriptional regulator SMAD3, DNA replication initiation factor MCM6 and Cyclin-dependent kinase CDK. This evidence concerns the gene IRF5 and chlamydia infectious disease.