Among the possible mechanisms behind CAF-mediated tumor growth regulation in vivo, it has been frequently observed an enhancement of angiogenesis during early phases of tumor formation via secretion of miscellaneous CAF-derived factors, including SDF-1/CXCL1235, CXCL1439, FGF-240, 41, PDGF42, IGF243, TGFβ44, 45 or CTGF46. The gene discussed is CXCL12; the disease is neoplasm.