Thus, the spatial disruption of myoepithelial and epithelial cells observed here leads in the case of SHH deregulation towards myoepithelial cell deficiency and tumor cell dissemination, and, in the case of SLIT2 deregulation, to a worsening of the local milieu, both having consequences for patient survival (Fig. 6). Here, SLIT2 is linked to neoplasm.