Additionally, although microphthalmia in ATF4-deficient mice precluded ONC in that genetic model (Masuoka and Townes, 2002), we found that daily dosing with ISRIB (10 mg/kg) for ten days (Figure 8—figure supplement 1) can also provide partial neuroprotection in this model (Figure 8c,d). Here, ATF4 is linked to microphthalmia.