NPTX2 and Alzheimer disease: NPTX2 was not reduced in brain of subjects who were cognitively normal at death but whose brains exhibit pathology typical of AD including Aß plaque and tangles [asymptomatic AD (ASYMAD) or preAD (Codispoti et al., 2012; Driscoll et al., 2006; Driscoll and Troncoso, 2011) (Figure 1F and G, and Figure 1—source data 1).