We determined that miR-1271 as well as its originating pri-miR, pre-mRNA and mRNA [miR-1271 is generated from intron of human gene Arl10 (ADP-ribosylation factor-like 10)] were increased in AD frontal cortex where levels in individual samples correlated with Nptx2 mRNA (Figure 2C, and Figure 2—figure supplement 2A). This evidence concerns the gene ARL10 and Alzheimer disease.