NPTX1/2/R levels did not correlate with Aß42 but did positively correlate with tau and p-tau within individual AD patients (Figure 5—figure supplement 5) and controls (NPTX2 vs tau, r = 0.4625, p=0.0002; NPTX2 vs p-tau, r = 0.3607, p=0.0043, Pearson correlation coefficient analysis). Here, NPTX2 is linked to Alzheimer disease.