NPTXR and Cognitive impairment: Nptx2-/- alone does not result in marked changes of PV interneuron function as assayed by gamma oscillations in vivo or in acute slices, but Nptx2-/- combined with Nptxr-/- resulted in a profound disruption of gamma oscillations and cognitive deficits in combination with a reduction of GluA4 protein in PV-interneurons (Pelkey et al., 2015, 2016).