FOURIER (Further Cardiovascular OUtcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk) is a multinational Phase 3 double-blind, randomized, placebo-controlled trial in 27,564 secondary prevention patients who had either myocardial infarction, an ischemic stroke or symptomatic peripheral artery disease on optimized statin therapy [161] (Fig. 4). Here, PCSK9 is linked to myocardial infarction.