LRRK2 and Parkinson disease: For example, Liu et al. found that lncRNA Homeobox (HOX) transcript antisense RNA (HOTAIR) was highly expressed in the midbrain of PD mice induced by MPTP (N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) and SH-SY5Y cells pre-treated with MPP+ (N-methyl-4-phenylpyridinium), and promoted the onset of PD induced by MPTP through regulating LPPK2 (leucine-rich repeat kinase 2) [9].