SLC12A2 and bacterial infectious disease: A potential mechanism that may explain the involvement of NKCC1 in edema formation and neutrophil transmigration was proposed by Matthay and Su (55), who speculated that expression of NKCC1 in endothelial and epithelial cells might be upregulated by inflammatory molecules in response to bacterial infections; however, this hypothesis still awaits functional validation, and regulatory pathways involved remain to be clarified.