TSHR and malignant colon neoplasm: For instance, 20% of all sequenced human tumors contain mutations in GPCRs, including mutations in the thyroid-stimulating hormone receptor (TSHR) (12), the luteinizing hormone receptor (LHR), and the follicle-stimulating hormone receptor (FSHR), known to be involved in thyroid, breast, lung, and colon cancers, respectively (13).