PTGS2 and Enchondromatosis: Schrage et al. (2010) analyzed COX-2 expression in cartilaginous tumors. They confirmed the expression of COX-2 in 65% of chondrosarcomas. They also found high COX-2 protein expression was mainly found in solitary peripheral chondrosarcoma and in enchondromatosis-related central chondrosarcoma, which was confirmed by qPCR. They emphasize the potential role of celecoxib in treatment (Schrage et al., 2010).