Yang et al. (2011), using microarray-based comparative genomic hybridization (aCGH), reported for the first time That vascular endothelial growth factor (VEGF) pathway genes, including the VEGFA protein, is overexpressed and play a role in poor prognosis and reduced survival in osteosarcoma (Yang et al., 2011). The gene discussed is VEGFA; the disease is osteosarcoma.