In particular, the use of candidate gene approaches has led to the identification of polymorphisms associated with PTSD risk in FKBP5, ADCYAP1R1, SERT, COMT, BDNF, GABRA2 and ApoE2 (reviewed in Lebois et al., 2016). This evidence concerns the gene ADCYAP1R1 and post-traumatic stress disorder.