A recent study performed differential label-free proteomics approach using 27 biopsies from patients with HCV-associated hepatic fibrosis and reported alterations in lumican (LUM), fibulin 5 (FBLN5), cysteine and glycine-rich protein 2 (CSRP2), calponin 2 (CNN2), transgelin (TAGLN), collagen alpha-1(XIV) chain (COL14A1), and MFAP-4, then verify the expression of these proteins on a transcriptional level and with targeted proteomic approach in different cohorts composed by a total of 77 and 68 HBV or HCV infected patients with liver fibrosis, respectively [19]. The gene discussed is FBLN5; the disease is Hepatic fibrosis.