In our study, we identified glycolysis as an altered pathway in HBV associated liver fibrosis due to changes in the DHE3, GAPDH and KPYM expression and also demonstrated altered expression of ALDH2 and ALDH1A1 which are the key members of alcohol metabolism contributing Acetyl Coenzyme A (Ac-CoA) production and ROS accumulation. This evidence concerns the gene GAPDH and Hepatic fibrosis.