In multiple myeloma (MM), P-selectin glycoprotein ligand-1 (PSGL-1), an L, P and E-selectin ligand,12, 13, 14, 15, 16, 17, 18, 19 has previously been shown to regulate homing to the bone marrow (BM), proliferation and resistance of malignant plasma cells to therapy mainly through its interaction with P-selectin.20, 21 However, in a recent study, a role of E-selectin together with P-selectin has been suggested during rolling of MM onto the BM microvasculature in vivo. This evidence concerns the gene SELP and plasma cell myeloma.