A study by Adams et al.,16 where participants with obesity (males and females) underwent 6 weeks of a VLED (7% WL), reported a reduction in hunger at 90 and 120 min, an increase in fullness at 120 min postprandial, as well as a decrease in postprandial total GLP-1 (but no changes in fasting). Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.