CCK and obesity due to melanocortin 4 receptor deficiency: Another study by Chearskul et al.19 with an 8-week VLED (429 kcal per day) in 12 males with obesity who experienced a 15% WL, did not report any changes in hunger or satiety feelings, or CCK concentration, either fasting or postprandial, immediately after the intervention, while in ketosis.