Along this line, we have recently reported that the combination of IFN-α (I) and epigenetic drugs, such as the DNA methyltransferase inhibitor (DNMTi) 5-azacitidine and the histone deacetylase inhibitor (HDACi) romidepsin (R) represents an efficacious antitumor treatment with a high potential to induce immunogenic apoptosis of colorectal cancer (CRC) cells8. This evidence concerns the gene IFNA1 and colorectal carcinoma.