TSHR and Graves disease: Given that the stimulation of thyrotropin receptor is the main mechanism of Graves' disease, our PTU‐induced mouse model of thyroid goiter shares similar features with Graves' disease, such as thyrotropin receptor hyper‐stimulation, hypertrophy of thyrocytes, and distinguishable characteristics of vascular remodeling (Nagura et al, 2001; Davies et al, 2005).