Among the 27 cytokines measured, IL-6, IL-7, IL-12, IL-13, and GM-CSF significantly increased while basic FGF, VEGF, IL-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-15, MIP-1β, and TNF-α decreased in both MSA-C and SCA compared with OND. This evidence concerns the gene TNF and autosomal dominant cerebellar ataxia.