Among these clusters, pleiotropic pro-inflammatory cytokines such as IL-1β and TNF-α, type 1 T helper cytokines such as IL-2 and IL-15, and type 2 T helper cytokines such as IL-5 and IL-10 all decreased significantly in MSA-C patients compared with OND patients. This evidence concerns the gene IL15 and multiple system atrophy, cerebellar type.