Regarding the pharmacokinetic parameter distribution, cisplatin ADRs may be influenced by the concentration of serum albumin and total proteins, considering 90% of the cisplatin in plasma is linked to proteins [7] and that it is common for cancer patients to present with hypoalbuminemia; it can be assumed that the amount of free cisplatin in the plasma of these patients will be dependent on the concentration of plasma proteins, and perhaps the ratio of plasma proteins and excretion of cisplatin/ADRs may be important. The gene discussed is ALB; the disease is cancer.