CXCL1 and metabolic dysfunction-associated steatohepatitis: However, given the reduction in macrophage infiltration identified in both treatment groups (siRNA and antibody), despite the discordant suppression of Cxcl10, it is possible that Cxcl10 does not play a crucial role in macrophage recruitment in the retina compared to Ccl2 and Cxcl1. While indeed plausible, other studies have shown that CXCL10 specifically elicits macrophage recruitment in experimental nonalcoholic steatohepatitis [39], and is also implicated in macrophage infiltration in kidney during puromycin aminonucleoside nephrosis [40].