FH patients also exhibited a greater state of endothelial activation, as indicated by higher concentrations of sICAM-1 (mean ± SD = 947 ± 742 vs 655 ± 191 ng/mL, p < 0.001) and E-selectin (mean ± SD = 175 ± 131 vs 21.6 ± 10.7 ng/mL, p < 0.001) compared to NC. The gene discussed is SELE; the disease is familial hyperaldosteronism.