In this study, we demonstrated that among patients with NTM diseases, specific HLA class II alleles (DRB*15, DRB1*16, DQB*05:01 and DQB1*05:02), comorbidities, history of previous OI and birthplace were significantly associated with an acquired anti IFN- γ autoantibody. The gene discussed is HLA-DRB1; the disease is osteogenesis imperfecta.