These data suggest that CRB3 may be a cancer suppressor, which is consistent with Karp and his colleagues’ previous findings that CRB3 expression correlates inversely with migration and invasion of the mouse kidney epithelial cells and that reduced expression of CRB3 can promote carcinogenesis of murine kidney epithelia.7 In human mammary epithelial cells, CRB3 downregulation was associated with stem cell molecular signatures, increased EMT and invasion potential, which are considered as hallmarks of CSC activity. Here, CRB3 is linked to cancer.