In human cancers, PDK1 deregulation in human malignancy can also be caused by gene amplification or abnormal phosphorylation in the cytosol and nucleus, such as in colon cancer and breast cancer.5, 12 In this study, we demonstrated that TCRP1 regulates the activity of PDK1, with the evidence of TCRP1 overexpression significantly increased PDK1 phosphoralation levels. The gene discussed is PDK1; the disease is breast cancer.