CDKN2A and Familial prostate cancer: In particular, it has been reported that ARF contributes to prostate cancer progression by stabilization through SUMO modification of Slug protein.37 Moreover, the ability of ARF to induce autophagy, a pro-survival mechanism related to the phenomenon of tumor dormancy,49 also points to the hypothesis that in particular cellular contexts ARF could have a pro-proliferative or even oncogenic role.