PTK2 and neoplasm: Cell adhesion to the substrate is primarily mediated by integrins that, connecting extracellular matrix with cytoskeleton, induce cell survival pathways including phosphorylation and activation of FAK,31, 32 whose activation strongly correlates with tumor aggressiveness, cell migration and proliferation.33, 34, 35 Here we provide evidence that p14ARF physically interacts with the FAK in its activated form.