Overexpression of H2AFY isoform 1.1 resulted in an increase in late CD71–CD235a+ erythroblasts (to 5.7% to 15.5%, i.e., a 1.54- to 1.85-fold increase) on day 14 in the three U2AF1S34F MDS patients, with a trend toward significance compared with the EV control (Figure 7H). Here, TFRC is linked to myelodysplastic syndrome.