To determine if changes in desaturase and elongase activities were related with their expression levels, liver mRNA gene expressions of ELOVL5, ELOVL6, FADS1, FADS2 and SCD1 were investigated by RT-Q-PCR on NASH compared to normal livers and NAFL matched NASH patients. Here, FADS1 is linked to metabolic dysfunction-associated steatohepatitis.