FADS2 and metabolic dysfunction-associated steatohepatitis: FADS2 and SCD1 activities were increased in accordance with the increase of monounsaturated (C16:1n-7 and C18:1n-9) and polyunsaturated (C18:2n-6) fatty acids in NASH (Fig. 4c and d, Supplemental Fig. S3b and c).