Although the role of interferon-γ (IFN-γ) in AOSD is controversial, signature IFN-γ–induced cytokines or chemokines, such as IL-18 or C-X-C motif chemokine 10 (CXCL10), are significantly elevated in AOSD5, 6, 7, 8. This evidence concerns the gene CXCL10 and adult-onset Still disease.