Subsequent immunohistochemical analyses of skin biopsies for CXCL9, CXCL10 and CXCL11, and their receptor, CXCR3, in 34 patients with active, untreated AOSD compared with normal skin and other inflammatory skin disorders, such as eczema and psoriasis, showed that the three IFN-γ induced chemokines and their receptor, CXCR3, were expressed in inflammatory cells of skin lesions in active AOSD patients. The gene discussed is CXCR3; the disease is inflammatory skin disease.