An analysis of serum chemokine levels with regard to AOSD manifestations showed that patients with a skin rash had a higher level of CXCL9 (667.6 ± 823.2 vs. 105.8 ± 84.8 pg/mL, p = 0.024) and CXCL10 (251.6 ± 191.2 vs. 79.4 ± 45.6 pg/mL, p = 0.021) than those without a rash. This evidence concerns the gene CXCL10 and adult-onset Still disease.