This study identified, for the first time, that ischaemia and hypoxia affects 15-LO expression in the brain vasculature, 15-LO/15-HETE promotes angiogenesis and neuronal recovery in late period of post-stroke mice and that 15-HETE stimulates proliferation and migration of BMVECs, via PI3K/Akt signalling. Here, AKT1 is linked to stroke disorder.