Further analysis of H&E lung sections to determine the area of metastatic burden revealed that the loss of LPP significantly reduces the size of metastatic lesions (LucA-shRNA versus LPP-shRNA) but the metastatic ability of breast cancer cells can be rescued by the expression of LPP-WT, LPP-245F and LPP-C. The gene discussed is LPP; the disease is breast carcinoma.