Re-expression of LPP-WT was able to fully restore the metastatic phenotype, while mutation of LPP tyrosine residue 245 (LPP-245F) or tyrosine residues 245/297/298 (LPP-C) to phenylalanine residues did not affect the metastatic ability of breast cancer cells. The gene discussed is LPP; the disease is breast cancer.