To assess whether loss of LPP phosphorylation on these sites also abrogates breast cancer metastasis, we injected NMuMG-ErbB2 cells expressing a panel of LPP phospho-mutants (Fig. 9a), along with LucA-shRNA control and LPP-shRNA cells into the mammary fat pads of immunocompromised mice (Fig. 10). Here, ERBB2 is linked to breast carcinoma.