A clear diminishment in both the number of lung surface lesions and the area of lung tissue occupied by breast cancer metastases was observed in animals injected with breast cancer cells harbouring an LPP-shRNA in both the NMuMG-ErbB2 and NIC models when compared with mice injected with cells containing LucA-shRNA (Fig. 1c,d). The gene discussed is ERBB2; the disease is breast cancer.