PDIA3 and amyotrophic lateral sclerosis: In addition, genetic evidence has placed the ER proteostasis network in the etiology of ALS as mutations in two‐disulfide isomerase (PDIA1 and ERp57) were proposed as risk factors to develop ALS (Gonzalez‐Perez et al., 2015; Woehlbier et al., 2016).