DNTT and T-cell and NK-cell neoplasm: The expression of TdT and the lack of surface IG are useful in distinguishing precursor B-cell disease from mature B-cell neoplasms, whereas the expression of TdT, CD34, and the presence of cytoplasmic CD3 without surface CD3 can be used to distinguish mature T-cell neoplasms from precursor T-cell disease [36].