CXCL2 and melanoma: B16-F10 murine melanoma was found to express high levels of CXCL1 and CXCL2, therefore leading to recruitment of TAN to the tumour.66 Human melanoma xenografts overexpressing murine CXCL6 in mice exhibited increased TAN influx and enhanced tumour growth.67 Similarly, CXCL8 overexpression in a human melanoma xenograft model led to increased neutrophil recruitment.21 Interestingly, CXCL8 expression is tightly associated with melanoma progression in patients,68 thereby prompting speculation that this pathway may contribute to increased N2 neutrophil prevalence with increased disease severity.