More importantly, these in vivo observations in mice translate into clinical evidence with expression of CXCL9 and CXCL10 in primary human melanoma correlating with increased CD8+ T-cell infiltration.57 Similarly, in metastatic melanoma, increased CD8+ T-cell infiltration was associated with enhanced expression of CCL3, CCL4, CCL5, CXCL9 and CXCL10.58 Furthermore, overexpression of CCR5 and CXCR3 ligands correlated with responsiveness to treatment. Here, CD8A is linked to metastatic melanoma.