In particular, chemotherapy with dacarbazine increased intratumoral CCL5, CXCL9 and CXCL10 expression, which was associated with increased tumour control in melanoma patients,55 while low-dose radiation promoted vascular normalisation and enhanced CXCL9, CXCL10 expression, together allowing for enhanced T-cell entry in vivo. This evidence concerns the gene CCL5 and melanoma.