For example, lineage tracing performed on the endothelium of tamoxifen-pulsed VE-cadheren-CreERT2 Rainbow mice engrafted with a B16 melanoma revealed a downregulation of CXCL9 and CXCL10 gene expression in melanoma endothelium with increased tumour progression.33 Furthermore, CXCL10 expression was found to be reduced with metastasis in a lung metastatic melanoma model, in which CXCL9 and CXCL10 expression were both inhibited by adenosine.56 This evidence concerns the gene CXCL9 and melanoma.