Furthermore, intratumoral vessels of metastatic melanoma patients also exhibit decreased P-selectin, E-selectin, ICAM-1 and VCAM-1 expression, although these are expressed strongly on non-tumoral blood vessels in adjacent tissue.30, 31, 32 This is also consistently observed in B16 murine melanoma models. The gene discussed is VCAM1; the disease is metastatic melanoma.