Interestingly, galectin-3 expression has been found to correlate with T-cell apoptosis in human melanoma biopsies, thereby potentially further inhibiting T-cell recruitment.50 Furthermore, galectin-3 has also been found to inhibit T-cell function, in particular IFN-γ secretion, through the inhibition of TCR and CD8 receptor association.51 Nonetheless, there is a lack of convincing evidence that these molecules are directly involved in monocyte and neutrophil recruitment in melanoma, thereby highlighting the need for further investigation. The gene discussed is LGALS3; the disease is melanoma.