Lineage tracing performed on the endothelium of tamoxifen-pulsed VE-cadherin-CreERT2 Rainbow mice engrafted with a B16 melanoma revealed the downregulation of gene expression levels of selectin, ICAM-1, VCAM-1 and MAdCAM-1 in melanoma endothelium compared to normal endothelium with disease progression.33 The gene discussed is CDH5; the disease is melanoma.