MOG and myeloid sarcoma: immune hyper-activity against antigens that leak from idiopathic myelin injury.27 Small-sized spontaneously appearing injuries in myelin have been detected in the MS brain in the form of microglia nodules28 and degenerating oligodendrocytes,29 which may actually be two sides of the same coin.30 The novel atypical marmoset EAE models revealed presence in the pathogen-educated primate immune system of autoaggressive T cells that are hyper-reactive against the CNS myelin component myelin oligodendrocyte glycoprotein (MOG).31