CD4 and myeloid sarcoma: The 4thR of Relevance: The usage of CFA introduces a mechanistic bias in the EAE model as immune responses against antigens formulated with CFA are skewed towards a pro-inflammatory CD4 dominated profile.21 The poor translation record of experimental therapies targeting CD4+ T cells from EAE to MS indicates that this cell subset may be less relevant in the human disease than in the animal model.22 However, this does not preclude a pathogenic role of CD4+ T cells early in the disease process, before the diagnosis has been made.