Very recently, Shuvaevet al.81 reported that the SCA1 82Q mouse line (SCA1-Tg; heterozygous B05 line carrying the human Ataxin-1 gene with 82 Q repeats under the control of the Purkinje cell-specific L7 promoter) generated by Burrightet al.72 exhibited progressive ataxia and impairment in multiple mGluR1 signaling at parallel fiber–Purkinje cell synapses from postnatal week 5 to 12, including TRPC3-mediated slow EPSCs, IP3-mediated local Ca2+ signaling in Purkinje cell dendrites, endocannabinoid-mediated short-term synaptic depression, and LTD81 (Table 1). The gene discussed is ATXN1; the disease is cerebellar ataxia.