They concluded that exercising is an appropriate preventive option for migraine in patients who do not benefit from drug therapy or are not willing to take daily medicine.31,42,45 Also, similar results obtained in Koseoglu et al.46 study that showed that aerobic exercise increased plasma beta-endorphin level, and consequently increased pain threshold in patients with migraine and reduced number and severity of headache attacks. The gene discussed is POMC; the disease is migraine disorder.