Epidemiologic studies on human populations reported a higher rate of mortality in acute ischemic stroke patients in association with lower IGF-I serum levels6,17,22-24 and lower serum levels of IGF-I in patients with ischemic and hemorrhagic stroke is in relationship with 1.5 and 5.2 times more mortality rate, respectively.25 Some studies have shown that exogenous IGF-I reduces neurological damage and neural defects in the acute phase after cerebral ischemic stroke within 24 hours to 7 days.26,27. This evidence concerns the gene IGF1 and hemorrhagic stroke.