Cerebrovascular accidents had a great outbreak in human society that can lead to severe disability and reduced quality of life.1 Ischemic stroke is defined as a loss of brain function due to deficiency in the blood supply caused by arterial embolism or thrombosis.2 In Western countries, stroke is the most common cause of death after heart diseases and before cancers.3 Although reperfusion by tissue plasminogen activator (tPA) is the approved acute treatment of ischemic stroke, a very small proportion of patients benefits it due to strict inclusion criteria and the limited time for treatment.4 The gene discussed is PLAT; the disease is Stroke.