Concurrent with the divergent roles of SPARC in carcinogenesis [15], our study also observed that SPARC altered the expression levels of microRNAs that regulate several signaling pathways involved in tumor progression including toll receptor signaling pathway, interleukin signaling pathway, apoptosis signaling pathway, angiogenesis signaling pathway, inflammation mediated chemokine and cytokine signaling pathway and platelet derived growth factor (PDGF) signaling pathway. This evidence concerns the gene SPARC and neoplasm.