Distinctive features of immunogenic apoptosis include the cell surface exposure of calreticulin (CRT) [39] and/or HSP90 [40] in pre- or early-apoptotic stages, as well as the release of non-histone chromatin protein high mobility group box 1 (HMGB1) by cancer cells in late-apoptosis or secondary necrosis [41]. The gene discussed is CALR; the disease is cancer.