The immunogenicity of cell death induced by DHA in MM cells was first indicated by the finding that MM apoptosis was associated with the correct spatiotemporally-defined cell surface exposure not only of CRT, as we showed in an earlier study on other tumor models [50], but also of HSP90, followed by the extra-cellular release of HMGB1, all specific DAMPs representing distinctive features of immunogenic apoptosis [27, 28, 38]. This evidence concerns the gene CALR and neoplasm.