In conclusion, our findings, indicating that DHA promotes immunogenic apoptosis in MM cells with no toxicity on PBMCs and DCs, activates autophagy and inhibits STAT3 in MM cells as well as in PBMCs and DCs, strongly encourage the potential use of this multi-target agent in cancer therapy either alone or in combinatorial strategies, to potentiate conventional immunogenic or non-immunogenic chemotherapies. The gene discussed is STAT3; the disease is Miyoshi myopathy.