In an experiment using euglycemic and hypoglycemic clamp in healthy individuals and type 1 diabetes patients [46], moderate hypoglycemia acutely increased circulating levels of PAI-1, VEGF, vascular adhesion molecules (VCAM, ICAM, E-selectin), IL-6, and markers of platelet activation (P-selectin) in individuals with type 1 diabetes and in healthy individuals. Here, SERPINE1 is linked to type 1 diabetes mellitus.