CCL2 and glomerulonephritis: Exposure to a high glucose milieu can enhance mesangial secretion of the monocyte chemoattractant protein-1 (MCP-1) resulting in macrophage accumulation and glomerulonephritis (Ihm et al., 1998, Wada et al., 2000), leading ultimately to fibrosis (Zeisberg and Neilson, 2010).