CD274 and colorectal carcinoma: This formed the basis of a phase Ib study that combined a MEK inhibitor, cobimetinib, with an anti-PD-L1 antibody, atezolizumab, in patients with advanced solid tumors (NCT01988896).The preliminary results from 23 CRC patients (22 KRAS mutant, 1 wild type) who have been treated with this combination showed that four patients (3 MMR-proficient, 1 unknown) achieved a PR and another five had SD [45].